2001 U.S. Men's Clay Court Championships – Singles

Fernando González was the defending champion but lost in the first round to Michal Tabara.

Andy Roddick won in the final 7–5, 6–3 against Hyung-Taik Lee.

Seeds
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.


 * 1) 🇺🇸 Jan-Michael Gambill (first round)
 * 2) 🇦🇺 Andrew Ilie (quarterfinals)
 * 3) 🇫🇷 Jérôme Golmard (semifinals)
 * 4) 🇨🇿 Michal Tabara (semifinals)
 * 5) 🇸🇪 Magnus Gustafsson (second round)
 * 6) 🇧🇪 Olivier Rochus (quarterfinals)
 * 7) 🇧🇪 Xavier Malisse (second round)
 * 8) 🇰🇷 Hyung-Taik Lee (final)