2001 US Open – Mixed doubles

Arantxa Sánchez Vicario and Jared Palmer were the defending champions, but lost in the quarterfinals to Ai Sugiyama and Ellis Ferreira.

Rennae Stubbs and Todd Woodbridge won the title by defeating Lisa Raymond and Leander Paes 6–4, 5–7, [11–9] in the final.

This was the first US Open to introduce a super tie-break in lieu of the final tie-break set

Seeds
• # 🇦🇺 Rennae Stubbs / 🇦🇺 Todd Woodbridge (champions)

• # 🇺🇸 Lisa Raymond / 🇮🇳 Leander Paes (final)

• # 🇺🇸 Kimberly Po-Messerli / 🇺🇸 Donald Johnson (semifinals)

• # 🇪🇸 Arantxa Sánchez Vicario / 🇺🇸 Jared Palmer (quarterfinals)

• # 🇯🇵 Ai Sugiyama / Ellis Ferreira (semifinals)

• # Jelena Dokic / 🇮🇳 Mahesh Bhupathi (first round)

• # 🇫🇷 Anne-Gaëlle Sidot / 🇦🇺 Sandon Stolle (quarterfinals)

• # 🇷🇺 Elena Likhovtseva / 🇺🇸 Brian MacPhie (first round)