2003 Italian Open – Women's singles

Kim Clijsters defeated Amélie Mauresmo in the final, 3–6, 7–6(7–3), 6–0 to win the women's singles tennis title at the 2003 Italian Open. It was her third title of the season, and the 13th overall in her career.

Serena Williams was the defending champion, but lost in semifinals to Mauresmo.

Seeds
The first eight seeds received a bye into the second round. • # 🇺🇸 Serena Williams (semifinals)

• # 🇧🇪 Kim Clijsters (champion)

• # 🇧🇪 Justine Henin-Hardenne (withdrew due to left knee tendinitis)

• # 🇫🇷 Amélie Mauresmo (final)

• # 🇺🇸 Jennifer Capriati (quarterfinals)

• # 🇺🇸 Chanda Rubin (second round)

• # 🇸🇰 Daniela Hantuchová (third round)

• # 🇷🇺 Anastasia Myskina (quarterfinals)

• # Jelena Dokic (first round)

• # 🇺🇸 Monica Seles (second round)

• # 🇧🇬 Magdalena Maleeva (second round)

• # Eleni Daniilidou (second round)

• # 🇯🇵 Ai Sugiyama (semifinals)

• # Amanda Coetzer (second round)

• # 🇺🇸 Meghann Shaughnessy (first round)

• # 🇮🇱 Anna Pistolesi (third round)

• # Patty Schnyder (third round)