2004 Italian Open – Women's singles

Amélie Mauresmo defeated Jennifer Capriati in the final, 3–6, 6–3, 7–6(8–6) to win the women's singles tennis title at the 2004 Italian Open. It was her second title of the season and the 12th of her career.

Kim Clijsters was the reigning champion, but did not compete this year due to a wrist injury.

Seeds
The first eight seeds received a bye into the second round. • # 🇺🇸 Serena Williams (semifinals)

• # 🇫🇷 Amélie Mauresmo (champion)

• # 🇷🇺 Anastasia Myskina (second round)

• # 🇷🇺 Nadia Petrova (second round)

• # 🇺🇸 Jennifer Capriati (final)

• # 🇷🇺 Elena Dementieva (second round)

• # 🇯🇵 Ai Sugiyama (third round)

• # 🇷🇺 Vera Zvonareva (semifinals)

• # 🇷🇺 Svetlana Kuznetsova (quarterfinals)

• # 🇮🇹 Silvia Farina Elia (quarterfinals)

• # Patty Schnyder (second round, retired due to a left upper arm strain)

• # 🇦🇷 Paola Suárez (third round)

• # 🇪🇸 Conchita Martínez (third round)

• # 🇮🇹 Francesca Schiavone (quarterfinals)

• # 🇧🇬 Magdalena Maleeva (first round)

• # 🇮🇱 Anna Smashnova-Pistolesi (quarterfinals)