2004 NASDAQ-100 Open – Women's singles

Two-time defending champion Serena Williams defeated Elena Dementieva in the final, 6–1, 6–1 to win the women's singles tennis title at the 2004 Miami Open.

This tournament marked the first career meeting between Serena Williams and Maria Sharapova; Williams won in straight sets in their fourth-round encounter.

Seeds
All seeded players received a bye into the second round. • # 🇺🇸 Serena Williams (champion)

• # 🇺🇸 Venus Williams (quarterfinals)

• # 🇷🇺 Anastasia Myskina (withdrew due to left toe sprain)

• # 🇺🇸 Jennifer Capriati (third round)

• # 🇷🇺 Elena Dementieva (final)

• # 🇯🇵 Ai Sugiyama (second round)

• # 🇷🇺 Vera Zvonareva (third round)

• # 🇷🇺 Nadia Petrova (semifinals)

• # 🇦🇷 Paola Suárez (fourth round)

• # 🇷🇺 Svetlana Kuznetsova (fourth round)

• # 🇮🇹 Silvia Farina Elia (third round)

• # 🇦🇺 Jelena Dokić (fourth round)

• # 🇮🇱 Anna Smashnova-Pistolesi (third round)

• # 🇧🇬 Magdalena Maleeva (second round)

• # 🇮🇹 Francesca Schiavone (fourth round)

• # 🇨🇴 Fabiola Zuluaga (second round)

• # 🇷🇺 Maria Sharapova (fourth round)

• # 🇪🇸 Magüi Serna (third round)

• # 🇺🇸 Meghann Shaughnessy (second round)

• # 🇺🇸 Lisa Raymond (third round)

• # 🇫🇷 Nathalie Dechy (quarterfinals)

• # Tina Pisnik (second round)

• # 🇷🇺 Dinara Safina (second round)

• # 🇦🇺 Alicia Molik (fourth round)

• # Eleni Daniilidou (semifinals)

• # 🇪🇸 María Sánchez Lorenzo (third round)

• # 🇸🇰 Daniela Hantuchová (third round)

• # 🇷🇺 Lina Krasnoroutskaya (second round)

• # Karolina Šprem (quarterfinals)

• # 🇭🇺 Petra Mandula (second round)

• # 🇷🇺 Elena Likhovtseva (third round)

• # 🇫🇷 Émilie Loit (third round)

Qualifying seeds
• # 🇮🇹 Flavia Pennetta (first round)

• # 🇮🇹 Rita Grande (qualified)

• # Marie-Gaïané Mikaelian (first round)

• # 🇮🇹 Mara Santangelo (qualified)

• # 🇨🇿 Sandra Kleinová (qualifying competition, Lucky loser)

• # 🇸🇰 Henrieta Nagyová (first round)

• # 🇪🇸 Marta Marrero (qualified)

• # 🇷🇺 Vera Dushevina (qualified)

• # 🇦🇷 Gisela Dulko (qualifying competition, Lucky loser)

• # 🇪🇸 Gala León García (first round)

• # 🇺🇸 Lindsay Lee-Waters (qualifiers)

• # Dally Randriantefy (first round)

• # Silvija Talaja (qualifying competition)

• # 🇨🇿 Eva Birnerová (first round)

• # 🇧🇦 Mervana Jugić-Salkić (first round)

• # 🇪🇸 Conchita Martínez Granados (qualifying competition)

• # 🇷🇺 Alina Jidkova (qualified)

• # 🇩🇪 Julia Schruff (qualifying competition)

• # 🇩🇪 Anna-Lena Grönefeld (qualifying competition)

• # 🇺🇸 Tara Snyder (qualified)

• # 🇸🇪 Sofia Arvidsson (first round)

• # 🇦🇺 Samantha Stosur (first round)

• # 🇨🇿 Barbora Strýcová (qualified)

• # 🇷🇺 Maria Kirilenko (qualified)

Qualifiers
• # 🇺🇸 Tara Snyder

• # 🇮🇹 Rita Grande

• # 🇷🇺 Alina Jidkova

• # 🇮🇹 Mara Santangelo

• # 🇨🇳 Sun Tiantian

• # 🇷🇺 Maria Kirilenko

• # 🇪🇸 Marta Marrero

• # 🇷🇺 Vera Dushevina

• # 🇨🇿 Barbora Strýcová

• # Ruxandra Dragomir Ilie

• # 🇺🇸 Lindsay Lee-Waters

• # 🇫🇷 Camille Pin

Lucky losers
• # 🇨🇿 Sandra Kleinová

• # 🇦🇷 Gisela Dulko