2005–06 Macedonian Second Football League

The 2005–06 Macedonian Second Football League was the fourteenth season since its establishment. It began on 6 August 2005 and ended on 20 May 2006.

Results
Every team will play three times against each other team for a total of 33 matches. The first 22 matchdays will consist of a regular double round-robin schedule. The league standings at this point will then be used to determine the games for the last 11 matchdays.