2005–06 Northern Iowa Panthers men's basketball team

The 2005–06 Northern Iowa Panthers men's basketball team represented the University of Northern Iowa during the 2005–06 NCAA Division I men's basketball season. The Panthers, led by fifth-year head coach Greg McDermott, played their home games at the UNI-Dome in Cedar Falls, Iowa and were members of the Missouri Valley Conference (The Valley). They finished the season 23–10, 11–7 in MVC play to finish in fifth place. They lost to Southern Illinois in the semifinals of the Missouri Valley tournament, but still received an at-large bid to the NCAA tournament where they were defeated by No. 7 seed Georgetown in the opening round.

Schedule and results
!colspan=9 style=| Exhibition

!colspan=9 style=| Non-Conference Regular season

!colspan=9 style=| Missouri Valley Conference Regular season

!colspan=9 style=| Missouri Valley tournament

!colspan=9 style=| NCAA tournament