2005 Abierto Mexicano Telcel – Men's singles

Carlos Moyá was the defending champion, but lost in the second round to Mariano Puerta.

Rafael Nadal won in the final 6–1, 6–0, against Albert Montañés.

Seeds
• # 🇪🇸 Carlos Moyá (second round)

• # 🇦🇷 Gastón Gaudio (first round, retired due to a pubalgia)

• # 🇦🇷 Guillermo Cañas (quarterfinals)

• # 🇦🇷 Juan Ignacio Chela (first round)

• # 🇨🇿 Jiří Novák (quarterfinals)

• # 🇮🇹 Filippo Volandri (quarterfinals)

• # 🇪🇸 David Ferrer (second round)

• # 🇪🇸 Rafael Nadal (champion)

Seeds
• # 🇪🇸 Rubén Ramírez Hidalgo (qualifying competition)

• # 🇦🇷 Edgardo Massa (qualified)

• # 🇪🇸 Marc López (qualifying competition)

• # 🇪🇨 Nicolás Lapentti (qualified)

• # 🇺🇸 Hugo Armando (qualifying competition)

• # 🇪🇸 Albert Portas (qualifying competition)

• # 🇦🇹 Oliver Marach (first round, retired)

• # 🇫🇷 Nicolas Devilder (qualified)

Qualifiers
• # 🇫🇷 Nicolas Devilder

• # 🇦🇷 Edgardo Massa

• # Juan Antonio Marín

• # 🇪🇨 Nicolás Lapentti