2005 Abierto Mexicano Telcel – Women's singles

Iveta Benešová was the defending champion, but did not compete this year.

Flavia Pennetta won the title by defeating Ľudmila Cervanová 3–6, 7–5, 6–3 in the final.

Seeds
• # 🇮🇹 Flavia Pennetta (champion)

• # 🇺🇸 Meghann Shaughnessy (second round)

• # 🇫🇷 Émilie Loit (quarterfinals)

• # 🇷🇺 Alina Jidkova (second round)

• # Dally Randriantefy (semifinals)

• # 🇪🇸 María Sánchez Lorenzo (first round)

• # 🇵🇱 Marta Domachowska (second round)

• # 🇪🇸 Nuria Llagostera Vives (first round)

Seeds
• # 🇪🇸 Laura Pous Tió (second round)

• # Vilmarie Castellvi (second round)

• # 🇨🇿 Kateřina Böhmová (qualifying competition)

• # 🇪🇸 Conchita Martínez Granados (first round)

• # 🇭🇺 Zsófia Gubacsi (first round)

• # 🇨🇿 Eva Birnerová (qualifying competition)

• # 🇪🇸 Paula García (second round)

• # 🇷🇺 Lioudmila Skavronskaia (first round)

Qualifiers
• # 🇭🇺 Ágnes Szávay

• # 🇪🇸 Rosa María Andrés Rodríguez

• # 🇦🇷 Erica Krauth

• # 🇺🇸 Julie Ditty