2005 Acura Classic – Singles

Mary Pierce defeated Ai Sugiyama in the final, 6–0, 6–3 to win the singles tennis title at the 2005 Southern California Open.

Lindsay Davenport was the reigning champion, but withdrew due to a lower-back strain.

Seeds
The top eight seeds received a bye into the second round. • # 🇺🇸 Lindsay Davenport (withdrew due to a lower-back strain)

• # 🇷🇺 Svetlana Kuznetsova (third round)

• # 🇷🇺 Elena Dementieva (second round)

• # 🇷🇺 Nadia Petrova (second round)

• # Patty Schnyder (quarterfinals)

• # 🇫🇷 Mary Pierce (champion)

• # 🇧🇪 Kim Clijsters (quarterfinals)

• # 🇷🇺 Vera Zvonareva (second round)

• # 🇷🇺 Elena Likhovtseva (third round)

• # 🇫🇷 Nathalie Dechy (third round)

• # Jelena Janković (third round)

• # 🇫🇷 Tatiana Golovin (first round)

• # 🇯🇵 Shinobu Asagoe (first round)

• # 🇸🇰 Daniela Hantuchová (second round)

• # 🇮🇹 Flavia Pennetta (second round)

• # 🇷🇺 Dinara Safina (third round)

• # 🇮🇹 Francesca Schiavone (third round)