2005 Australian Open – Mixed doubles

Samantha Stosur and Scott Draper defeated Liezel Huber and Kevin Ullyett in the final 6–2, 2–6, [10–6] to win the mixed doubles title at the 2005 Australian Open. This was the first Grand Slam title for both Stosur and Draper, and would be Draper's only Grand Slam title.

Elena Bovina and Nenad Zimonjić were the defending champions, but Bovina did not compete due to a left foot injury. Zimonjić participated with Elena Likhovtseva, and the pair lost in the second round to Stosur and Draper.

Seeds
• # 🇦🇺 Rennae Stubbs / 🇨🇦 Daniel Nestor (quarterfinals)

• # Cara Black / Wayne Black (quarterfinals)

• # 🇪🇸 Conchita Martínez / 🇮🇱 Andy Ram (semifinals)

• # Liezel Huber /  Kevin Ullyett (final)

• # 🇷🇺 Vera Zvonareva / 🇺🇸 Bob Bryan (quarterfinals)

• # 🇷🇺 Elena Likhovtseva / Nenad Zimonjić (second round)

• # 🇺🇸 Martina Navratilova / 🇧🇾 Max Mirnyi (semifinals)

• # 🇸🇰 Janette Husárová / 🇨🇿 Leoš Friedl (second round)