2005 Campbell's Hall of Fame Tennis Championships – Singles

Greg Rusedski was the defending champion. Rusedski successfully defended his title, beating Vincent Spadea in the final, 7–6(7–3), 2–6, 6–4.

Seeds
• # 🇺🇸 Taylor Dent (second round)

• # 🇺🇸 Vincent Spadea (final)

• # 🇬🇧 Greg Rusedski (champion)

• # 🇫🇷 Cyril Saulnier (first round)

• # 🇺🇸 Robby Ginepri (second round)

• # 🇩🇪 Lars Burgsmüller (first round, retired due to a leg injury)

• # 🇺🇸 Paul Goldstein (semifinals)

• # 🇺🇸 James Blake (first round)