2005 Campionati Internazionali di Sicilia – Singles

Tomáš Berdych was the defending champion, but lost in the first round to Andreas Seppi.

Igor Andreev won the title by defeating Filippo Volandri 0–6, 6–1, 6–3 in the final.

Seeds
• # 🇪🇸 David Ferrer (first round)

• # 🇪🇸 Tommy Robredo (quarterfinals)

• # 🇪🇸 Juan Carlos Ferrero (quarterfinals)

• # 🇨🇿 Tomáš Berdych (first round)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇮🇹 Filippo Volandri (final)

• # 🇫🇷 Gaël Monfils (first round)

• # 🇮🇹 Davide Sanguinetti (quarterfinals)