2005 Cellular South Cup – Singles

Vera Zvonareva was the defending champion and successfully defended her title by defeating Meghann Shaughnessy 7–6(7–3), 6–2 in the final.

Seeds
• # 🇷🇺 Vera Zvonareva (champion)

• # 🇺🇸 Amy Frazier (first round)

• # 🇺🇸 Meghann Shaughnessy (final)

• # 🇸🇰 Martina Suchá (first round)

• # 🇺🇸 Mashona Washington (first round)

• # 🇷🇺 Alina Jidkova (first round)

• # 🇨🇿 Nicole Vaidišová (semifinals)

• # 🇷🇺 Evgenia Linetskaya (semifinals)