2005 ECM Prague Open – Men's singles

The men's singles of the 2005 ECM Prague Open tournament was played on clay in Prague, Czech Republic.

Jan Hernych successfully defended his title, by defeating Jiří Vaněk 3–6, 6–4, 6–3 in the final.

Seeds
• # 🇨🇿 Tomáš Zíb (second round)

• # 🇨🇿 Jan Hernych (champion)

• # Peter Wessels (first round)

• # 🇫🇷 Gaël Monfils (quarterfinals)

• # Raemon Sluiter (first round)

• # 🇨🇾 Marcos Baghdatis (first round)

• # 🇨🇿 Jiří Vaněk (final)

• # 🇨🇿 Michal Tabara (second round)