2005 ECM Prague Open – Women's singles

The women's singles of the 2005 ECM Prague Open tournament was played on clay in Prague, Czech Republic.

This event was last held in 1998.

Dinara Safina won the title.

Seeds
• # 🇷🇺 Dinara Safina (Winner)

• # 🇨🇿 Klára Koukalová (semifinals)

• # Jelena Kostanić (second round)

• # 🇪🇸 Nuria Llagostera Vives (withdrew due to a right quadriceps sprain)

• # 🇨🇿 Iveta Benešová (quarterfinals)

• # 🇹🇭 Tamarine Tanasugarn (first round)

• # 🇩🇪 Marlene Weingärtner (first round)

• # 🇸🇰 Martina Suchá (first round)

• # 🇪🇸 Arantxa Parra Santonja (first round)