2005 Eastern Illinois Panthers football team

The 2005 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Ohio Valley Conference (OVC) during the 2005 NCAA Division I-AA football season. Led by 19th-year head coach Bob Spoo, the Panthers compiled an overall record of 9–3 with a mark of 8–0 in conference play, winning the OVC title. Eastern Illinois was invited to the NCAA Division I-AA Football Championship playoffs, where they lost Southern Illinois in the first round.