2005 Family Circle Cup – Singles

Justine Henin-Hardenne defeated Elena Dementieva in the final, 7–5, 6–4 to win the singles tennis title at the 2005 Family Circle Cup.

Venus Williams was the defending champion, but lost in the third round to Tatiana Golovin.

Seeds
The top eight seeds received a bye into the second round. • # 🇺🇸 Lindsay Davenport (quarterfinals, retired due to a right hip flexor strain)

• # 🇷🇺 Elena Dementieva (final)

• # 🇷🇺 Anastasia Myskina (second round)

• # 🇺🇸 Venus Williams (third round)

• # 🇦🇺 Alicia Molik (withdrew due to an inner ear infection)

• # 🇷🇺 Vera Zvonareva (second round)

• # 🇷🇺 Nadia Petrova (quarterfinals)

• # Patty Schnyder (semifinals)

• # 🇷🇺 Elena Likhovtseva (first round)

• # Jelena Janković (first round)

• # 🇯🇵 Ai Sugiyama (third round)

• # 🇮🇹 Silvia Farina Elia (first round)

• # 🇫🇷 Tatiana Golovin (semifinals)

• # 🇯🇵 Shinobu Asagoe (third round)

• # 🇫🇷 Mary Pierce (second round)

• # 🇨🇴 Fabiola Zuluaga (second round)