2005 Guangzhou International Women's Open – Singles

Li Na was the defending champion, but lost in the quarterfinals to Yan Zi.

Yan reached the final, where she was leading 6–4, 4–0 when her opponent Nuria Llagostera Vives retired due to a hamstring injury, giving Yan the title.

Seeds
• #🇷🇺 Vera Zvonareva (first round)

• #🇨🇳 Peng Shuai (second round, retired due to heat illness)

• #🇨🇳 Li Na (quarterfinals)

• #🇷🇺 Maria Kirilenko (quarterfinals)

• #🇨🇳 Zheng Jie (semifinals)

• #🇪🇸 Nuria Llagostera Vives (final, retired due to a hamstring injury)

• #🇵🇱 Marta Domachowska (second round)

• #🇸🇰 Martina Suchá (second round)