2005 Internazionali Femminili di Palermo – Singles

Anabel Medina Garrigues was the defending champion and successfully defender her title, by defeating Klára Koukalová 6–4, 6–0 in the final.

Seeds
• # 🇮🇹 Silvia Farina Elia (first round, retired)

• # 🇮🇹 Flavia Pennetta (semifinals)

• # 🇪🇸 Anabel Medina Garrigues (champion)

• # 🇪🇸 Nuria Llagostera Vives (second round)

• # 🇨🇿 Klára Koukalová (final)

• # 🇵🇱 Marta Domachowska (second round)

• # 🇮🇹 Roberta Vinci (quarterfinals)

• # Katarina Srebotnik (first round)