2005 Internazionali di Modena – Singles

This was the first edition of the tournament, so no defending champions were declared.

Anna Smashnova won the title, defeating Tathiana Garbin in the final. Smashnova was leading 3–0 on the first set tiebreak, when Garbin suffered a heat illness during the match and decided to retire. It was the first title of the year for Smashnova and the 16th of her career.

Seeds
• # 🇮🇹 Francesca Schiavone (quarterfinals)

• # 🇮🇹 Flavia Pennetta (semifinals)

• # 🇨🇿 Klára Koukalová (withdrew due to an illness)

• # 🇵🇱 Marta Domachowska (first round)

• # 🇮🇱 Anna Smashnova (champion)

• # Jelena Kostanić (second round)

• # 🇮🇹 Antonella Serra Zanetti (first round)

• # 🇦🇷 Mariana Díaz Oliva (quarterfinals)

• # 🇮🇹 Maria Elena Camerin (withdrew due to a right shoulder tendonitis)