2005 Pilot Pen Tennis – Women's singles

Elena Bovina was the defending champion, but did not compete this year due to a right shoulder injury.

Lindsay Davenport won the title, defeating Amélie Mauresmo 6–4, 6–4 in the final.

Seeds
The first four seeds received a bye into the second round. • # 🇺🇸 Lindsay Davenport (champion)

• # 🇫🇷 Amélie Mauresmo (final)

• # 🇷🇺 Svetlana Kuznetsova (withdrew due to a mid-back strain)

• # 🇷🇺 Elena Dementieva (quarterfinals)

• # 🇷🇺 Nadia Petrova (withdrew due to a right pectoralis strain)

• # Patty Schnyder (second round)

• # 🇦🇺 Alicia Molik (first round)

• # 🇷🇺 Anastasia Myskina (withdrew due to a left ankle sprain)

• # 🇫🇷 Nathalie Dechy (first round)

• # Jelena Janković (first round)