2005 Prairie View A&M Panthers football team

The 2005 Prairie View A&M Panthers football team represented Prairie View A&M University as a member of the Southwestern Athletic Conference (SWAC) during the 2005 NCAA Division I-AA football season. Led by second-year head coach Henry Frazier III, the Panthers compiled an overall record of 5–6, with a mark of 3–6 in conference play, and finished tied for third in the SWAC West Division.