2005 Regions Morgan Keegan Championships – Singles

Joachim Johansson was the defending champion, but did not participate.

Kenneth Carlsen won the title, defeating Max Mirnyi in the final 7–5, 7–5.

Seeds
• # 🇺🇸 Andy Roddick (semifinals, withdrew due to ankle sprain)

• # 🇩🇪 Tommy Haas (semifinals)

• # 🇺🇸 Vince Spadea (second round, retired due to a shoulder injury)

• # 🇨🇿 Jiří Novák (first round)

• # 🇧🇪 Xavier Malisse (quarterfinals)

• # 🇺🇸 Mardy Fish (second round)

• # 🇦🇹 Jürgen Melzer (first round)

• # 🇧🇾 Max Mirnyi (final)