2005 Tashkent Open – Singles

Nicole Vaidišová was the defending champion, but chose not to participate that year.

16-year-old Michaëlla Krajicek won the title, upsetting home-crowd-favourite Akgul Amanmuradova 6–0, 4–6, 6–3 in the final.

Seeds
• # 🇷🇺 Ekaterina Bychkova (semifinals)

• # 🇺🇦 Alona Bondarenko (first round)

• # 🇮🇹 Antonella Serra Zanetti (quarterfinals)

• # 🇫🇮 Emma Laine (second round)

• # Michaëlla Krajicek (champion)

• # 🇫🇷 Émilie Loit (first round)

• # 🇮🇹 Maria Elena Camerin (semifinals)

• # 🇮🇹 Mara Santangelo (first round)