2005 US Open – Girls' singles

The United States Open Tennis Championships is a hardcourt tennis tournament held annually at Flushing Meadows, starting on the last Monday in August and lasting for two weeks. The tournament consists of five main championship events: men's and women's singles, men's and women's doubles, and mixed doubles, with additional tournaments for seniors, juniors, and wheelchair players.

The event was won by Victoria Azarenka of Belarus who beat Alexa Glatch of the United States, 6–3, 6–4 in the final.

Seeds
• # 🇧🇾 Victoria Azarenka (champion)

• # 🇵🇱 Agnieszka Radwańska (second round)

• # 🇸🇰 Dominika Cibulková (quarterfinals)

• # Caroline Wozniacki (first round)

• # 🇷🇴 Alexandra Dulgheru (first round)

• # 🇳🇿 Marina Erakovic (quarterfinals)

• # 🇺🇸 Alexa Glatch (final)

• # 🇺🇸 Mary Gambale (second round)

• # 🇷🇺 Ekaterina Makarova (third round)

• # 🇺🇸 Vania King (third round)

• # Wen-Hsin Hsu (third round)

• # 🇯🇵 Ayumi Morita (first round)

• # Bibiane Schoofs (third round)

• # 🇷🇴 Mihaela Buzărnescu (semifinals)

• # 🇺🇸 Jennifer-Lee Heinser (first round)

• # 🇰🇿 Amina Rakhim (first round)