2006 İstanbul Cup – Singles

Venus Williams was the defending champion, but did not compete this year.

Shahar Pe'er won the title by defeating Anastasia Myskina 1–6, 6–3, 7–6(7–3) in the final.

Seeds
The top two seeds received a bye into the second round. • # 🇷🇺 Anastasia Myskina (final)

• # 🇩🇪 Anna-Lena Grönefeld (semifinals)

• # 🇷🇺 Anna Chakvetadze (first round)

• # 🇮🇱 Shahar Pe'er (champion)

• # 🇮🇳 Sania Mirza (second round)

• # 🇨🇴 Catalina Castaño (quarterfinals)

• # 🇮🇹 Mara Santangelo (quarterfinals)

• # Jelena Kostanić (first round)