2006 Abierto Mexicano Telcel – Men's singles

Rafael Nadal was the defending champion, but did not participate this year.

Luis Horna won the title, defeating Juan Ignacio Chela 7–6(7–5), 6–4 in the final.

Seeds

 * 1) 🇦🇷 Guillermo Coria (first round)
 * 2) 🇦🇷 Gastón Gaudio (semifinals)
 * 3) 🇪🇸 Carlos Moyá (second round)
 * 4) 🇮🇹 Filippo Volandri (first round)
 * 5) 🇦🇷 José Acasuso (second round, retired because of a right foot injury)
 * 6) 🇫🇷 Florent Serra (first round)
 * 7) 🇦🇷 Juan Ignacio Chela (final)
 * 8)  Nicolás Massú (second round)