2006 Acura Classic – Singles

Maria Sharapova defeated Kim Clijsters in the final, 7–5, 7–5 to win the singles tennis title at the 2006 Southern California Open.

Mary Pierce was the defending champion, but lost in the quarterfinals to Sharapova.

Seeds
The top eight seeds received a bye into the second round. • # 🇧🇪 Kim Clijsters (final)

• # 🇷🇺 Maria Sharapova (champion)

• # 🇷🇺 Nadia Petrova (second round)

• # 🇷🇺 Elena Dementieva (quarterfinals)

• # Patty Schnyder (semifinals)

• # 🇫🇷 Mary Pierce (quarterfinals)

• # 🇨🇿 Nicole Vaidišová (semifinals)

• # Martina Hingis (quarterfinals)

• # 🇷🇺 Dinara Safina (first round)

• # 🇩🇪 Anna-Lena Grönefeld (first round)

• # 🇸🇰 Daniela Hantuchová (third round)

• # 🇮🇹 Flavia Pennetta (third round)

• # 🇯🇵 Ai Sugiyama (first round)

• # Ana Ivanovic (third round)

• # Katarina Srebotnik (second round)

• # 🇷🇺 Maria Kirilenko (first round)