2006 Brasil Open – Singles

Rafael Nadal was the defending champion, but chose not to participate that year.

Nicolás Massú won in the final 6–3, 6–4, against Alberto Martín.

Seeds
• # 🇦🇷 Gastón Gaudio (second round)

• # 🇪🇸 Juan Carlos Ferrero (first round)

• # 🇮🇹 Filippo Volandri (second round)

• # 🇫🇷 Florent Serra (second round)

• # 🇦🇷 Juan Ignacio Chela (quarterfinals)

• # Nicolás Massú (champion)

• # 🇪🇸 Alberto Martín (final)

• # Boris Pašanski (quarterfinals)