2006 Campbell's Hall of Fame Tennis Championships – Singles

Greg Rusedski was the defending champion, but did not participate.

Mark Philippoussis defeated Justin Gimelstob in the final 6–3, 7–5.

Seeds
• # 🇬🇧 Andy Murray (semifinals)

• # Ivo Karlović (first round, retired)

• # 🇺🇸 Paul Goldstein (first round)

• # 🇱🇺 Gilles Müller (first round)

• # 🇺🇸 Vince Spadea (first round)

• # 🇦🇹 Jürgen Melzer (semifinals)

• # 🇺🇸 Mardy Fish (quarterfinals)

• # 🇺🇸 Justin Gimelstob (final)