2006 Campionati Internazionali di Sicilia – Singles

In the 2006 Campionati Internazionali di Sicilia singles event, Igor Andreev was the defending champion, but did not participate.

Filippo Volandri won the title, defeating Nicolás Lapentti 5–7, 6–1, 6–3 in the final.

Seeds
• # 🇪🇸 Fernando Verdasco (quarterfinals)

• # 🇮🇹 Filippo Volandri (champion)

• # 🇫🇷 Gilles Simon (quarterfinals)

• # 🇪🇸 Nicolás Almagro (semifinals, retired due to an ankle injury)

• # 🇫🇷 Paul-Henri Mathieu (first round)

• # 🇩🇪 Florian Mayer (withdrew due to a sore shoulder)

• # 🇵🇪 Luis Horna (first round, retired due to a shoulder injury)

• # 🇪🇸 Rubén Ramírez Hidalgo (semifinals)