2006 Delray Beach International Tennis Championships – Singles

Xavier Malisse was the defending champion but lost in the final 6–3, 3–6, 7–6(7–5) against Tommy Haas.

Seeds

 * 1) 🇺🇸 Andre Agassi (quarterfinals)
 * 2) 🇺🇸 Robby Ginepri (first round)
 * 3) 🇧🇪 Xavier Malisse (final)
 * 4) 🇩🇪 Tommy Haas (champion)
 * 5)  Wesley Moodie (first round)
 * 6) 🇩🇪 Florian Mayer (quarterfinals)
 * 7) 🇱🇺 Gilles Müller (quarterfinals)
 * 8) 🇺🇸 Vince Spadea (semifinals)