2006 ECM Prague Open – Men's singles

The men's singles of the 2006 ECM Prague Open tournament was played on clay in Prague, Czech Republic.

Jan Hernych was the defending champion, but lost in second round to Tomáš Zíb.

Robin Vik won the title by defeating Jan Hájek 6–4, 7–6(7–4) in the final.

Seeds
• # 🇨🇿 Robin Vik (champion)

• # 🇨🇿 Jan Hernych (second round)

• # 🇨🇿 Lukáš Dlouhý (second round)

• # 🇦🇷 Carlos Berlocq (first round)

• # 🇫🇷 Julien Benneteau (first round)

• # 🇨🇿 Jiří Vaněk (first round)

• # 🇪🇸 Albert Montañés (second round)

• # Ramón Delgado (second round)