2006 ECM Prague Open – Women's singles

The women's singles of the 2006 ECM Prague Open tournament was played on clay in Prague, Czech Republic.

Dinara Safina was the defending champion, but competed in Berlin at the same week.

Shahar Pe'er won the title by defeating Samantha Stosur 4–6, 6–2, 6–1 in the final.

Seeds
• # 🇫🇷 Marion Bartoli (first round)

• # 🇨🇿 Lucie Šafářová (first round)

• # 🇮🇱 Shahar Pe'er (champion)

• # 🇫🇷 Émilie Loit (quarterfinals)

• # 🇦🇺 Samantha Stosur (final)

• # 🇮🇹 Maria Elena Camerin (quarterfinals)

• # 🇨🇳 Peng Shuai (semifinals)

• # 🇺🇦 Alona Bondarenko (quarterfinals)