2006 Estoril Open – Women's singles

Lucie Šafářová was the defending champion, but did not compete this year.

Zheng Jie won the title with the score tied at 1 set all, after her opponent Li Na was forced to retire due to a heat illness. It was the first title of the year for Zheng and the second title in her career.

Seeds
• # 🇮🇹 Flavia Pennetta (semifinals)

• # 🇦🇷 Gisela Dulko (quarterfinals)

• # 🇪🇸 Lourdes Domínguez Lino (quarterfinals)

• # 🇮🇹 Roberta Vinci (withdrew due to a right leg injury)

• # 🇷🇺 Vera Dushevina (first round)

• # 🇨🇳 Zheng Jie (champion)

• # 🇫🇷 Émilie Loit (semifinals)

• # 🇨🇳 Li Na (final, retired due to a heat illness)

• # 🇫🇷 Virginie Razzano (first round)