2006 Grand Prix de Tennis de Lyon – Singles

Andy Roddick was the defending champion, but did not participate this year.

Richard Gasquet won the tournament, beating Marc Gicquel 6–3, 6–1 in the final.

Seeds
• # 🇨🇾 Marcos Baghdatis (first round)

• # 🇦🇷 Gastón Gaudio (first round)

• # 🇸🇰 Dominik Hrbatý (second round)

• # 🇫🇷 Richard Gasquet (champion)

• # 🇸🇪 Robin Söderling (quarterfinals)

• # 🇫🇷 Sébastien Grosjean (quarterfinals)

• # 🇧🇪 Xavier Malisse (semifinals)

• # 🇪🇸 Nicolás Almagro (quarterfinals)