2006 Guangzhou International Women's Open – Singles

Yan Zi was the defending champion, but lost in first round to Olga Puchkova.

Anna Chakvetadze won the title, defeating Anabel Medina Garrigues in the final 6–1, 6–4.

Seeds
• # Jelena Janković (semifinals, retired due to a heat illness)

• # 🇨🇳 Li Na (quarterfinals)

• # 🇷🇺 Anna Chakvetadze (champion)

• # 🇪🇸 Anabel Medina Garrigues (final)

• # 🇪🇸 Lourdes Domínguez Lino (second round)

• # 🇺🇸 Meghann Shaughnessy (first round)

• # 🇷🇺 Elena Vesnina (second round)

• # 🇧🇾 Anastasiya Yakimova (second round)