2006 Internazionali Femminili di Palermo – Singles

Anabel Medina Garrigues was the 2-time defending champion and successfully defended her title, by defeating Tathiana Garbin 6–4, 6–4 in the final.

Seeds
• # 🇮🇹 Flavia Pennetta (first round)

• # 🇪🇸 Anabel Medina Garrigues (champion)

• # Michaëlla Krajicek (second round)

• # 🇨🇿 Lucie Šafářová (semifinals)

• # 🇮🇱 Anna Smashnova (second round)

• # 🇨🇿 Klára Koukalová (second round)

• # 🇨🇿 Iveta Benešová (second round)

• # 🇪🇸 Lourdes Domínguez Lino (second round)