2006 Jacksonville State Gamecocks football team

The 2006 Jacksonville State Gamecocks football team represented Jacksonville State University as a member of the Ohio Valley Conference (OVC) during the 2006 NCAA Division I-AA football season. Led by Seventh-year head coach Jack Crowe, the Gamecocks compiled an overall record of 6–5 with a mark of 5–3 in conference play, tying for fourth place in the OVC. Jacksonville State played home games at Paul Snow Stadium in Jacksonville, Alabama.