2006 Kremlin Cup – Men's singles

Igor Andreev was the defending champion, but did not compete this year.

Nikolay Davydenko won in the final 6–4, 5–7, 6–4 against Marat Safin.

Seeds
• # 🇷🇺 Nikolay Davydenko (champion)

• # 🇷🇺 Dmitry Tursunov (first round)

• # 🇷🇺 Mikhail Youzhny (first round)

• # 🇪🇸 Fernando Verdasco (first round, retired due to illness)

• # 🇮🇹 Filippo Volandri (first round)

• # 🇫🇷 Julien Benneteau (second round)

• # 🇫🇷 Fabrice Santoro (semifinals)

• # 🇫🇷 Paul-Henri Mathieu (first round)