2006 Kremlin Cup – Women's singles

Anna Chakvetadze defeated Nadia Petrova in the final, 6–4, 6–4 to win the women's singles tennis title at the 2006 Kremlin Cup.

Mary Pierce was the reigning champion, but did not compete this year.

Seeds
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated. The top four seeds received a bye to the second round.

• # 🇫🇷 Amélie Mauresmo (quarterfinals)

• # 🇷🇺 Maria Sharapova (quarterfinals, withdrew due to right foot strain)

• # 🇷🇺 Svetlana Kuznetsova (second round)

• # 🇷🇺 Elena Dementieva (semifinals)

• # 🇷🇺 Nadia Petrova (final)

• # Patty Schnyder (quarterfinals)

• # 🇷🇺 Dinara Safina (first round)

• # 🇨🇿 Nicole Vaidišová (semifinals)