2006 Medibank International – Men's singles

Lleyton Hewitt was the defending champion, but lost in the quarterfinals to Andreas Seppi.

James Blake won in the final 6–2, 3–6, 7–6(7–3) against Igor Andreev.

Seeds
• # 🇦🇺 Lleyton Hewitt (quarterfinals)

• # 🇷🇺 Nikolay Davydenko (semifinals)

• # 🇸🇪 Thomas Johansson (withdrew due to triceps injury)

• # 🇫🇷 Richard Gasquet (first round)

• # 🇪🇸 Juan Carlos Ferrero (first round)

• # 🇪🇸 Tommy Robredo (first round)

• # 🇫🇷 Radek Štěpánek (first round)

• # 🇺🇸 James Blake (champion)