2006 Medibank International – Women's singles

Alicia Molik was the defending champion, but was unable to compete due to vestibular neuronitis.

Justine Henin-Hardenne won the title, defeating Francesca Schiavone 4–6, 7–5, 7–5 in the final.

Seeds
• # 🇧🇪 Kim Clijsters (quarterfinals, withdrew due to a hip injury)
 * The top four seeds receive a bye into the second round

• # 🇫🇷 Amélie Mauresmo (second round)

• # Patty Schnyder (second round)

• # 🇷🇺 Nadia Petrova (quarterfinals, withdrew due to an ankle strain)

• # 🇧🇪 Justine Henin-Hardenne (champion)

• # 🇷🇺 Svetlana Kuznetsova (semifinals)

• # 🇮🇹 Francesca Schiavone (final)

• # 🇨🇿 Nicole Vaidišová (semifinals)