2006 Mississippi Valley State Delta Devils football team

The 2006 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the Southwestern Athletic Conference (SWAC) during the 2006 NCAA Division I FCS football season. Led by fifth-year head coach Willie Totten, the Delta Devils compiled an overall record of 6–5 and a mark of 5–4 in conference play, and finished tied for third in the SWAC East Division.