2006 Mondial Australian Women's Hardcourts – Singles

Patty Schnyder was the defending champion, but lost in quarterfinals to Lucie Šafářová.

Lucie Šafářová won the title by defeating Flavia Pennetta 6–3, 6–4 in the final.

Seeds
• # Patty Schnyder (quarterfinals)

• # 🇮🇹 Francesca Schiavone (second round)

• # 🇷🇺 Dinara Safina (semifinals)

• # 🇮🇹 Flavia Pennetta (final)

• # 🇫🇷 Tatiana Golovin (quarterfinals)

• # 🇯🇵 Ai Sugiyama (first round)

• # 🇨🇿 Klára Koukalová (second round)

• # 🇪🇸 Anabel Medina Garrigues (quarterfinals)