2006 Monte Carlo Masters – Singles

Defending champion Rafael Nadal defeated Roger Federer in the final, 6–2, 6–7(2–7), 6–3, 7–6(7–5) to win the singles tennis title at the 2006 Monte Carlo Masters.

This tournament marked the first professional-level match played between Novak Djokovic and Federer, who would go on to play a total of 50 ATP Tour-level matches against each other; Federer won their first-round encounter.

Seeds
• # Roger Federer (final)

• # 🇪🇸 Rafael Nadal (champion)

• # 🇦🇷 David Nalbandian (third round)

• # Ivan Ljubičić (quarterfinals)

• # 🇷🇺 Nikolay Davydenko (first round)

• # 🇦🇷 Guillermo Coria (quarterfinals)

• # 🇦🇷 Gastón Gaudio (semifinals)

• # 🇪🇸 David Ferrer (quarterfinals)

• # 🇩🇪 Nicolas Kiefer (third round)

• # 🇨🇿 Radek Štěpánek (second round)

• # 🇪🇸 Juan Carlos Ferrero (third round)

• # Fernando González (semifinals)

• # 🇫🇷 Sébastien Grosjean (second round, retired because of a back injury)

• # 🇫🇮 Jarkko Nieminen (first round)

• # 🇪🇸 Tommy Robredo (quarterfinals)

• # 🇨🇿 Tomáš Berdych (second round)

Qualifying seeds
• # Novak Djokovic (qualified)

• # 🇮🇹 Daniele Bracciali (qualifying competition, lucky loser)''

• # 🇸🇪 Jonas Björkman (qualifying competition)

• # 🇩🇪 Florian Mayer (first round)

• # 🇩🇪 Björn Phau (first round, retired)

• # 🇮🇹 Potito Starace (qualified)

• # 🇫🇷 Nicolas Mahut (qualified)

• # 🇮🇹 Alessio di Mauro (qualified)

• # 🇨🇿 Jan Hernych (qualified)

• # 🇪🇸 Rubén Ramírez Hidalgo (qualifying competition)

• # 🇪🇸 Guillermo García López (qualifying competition)

• # 🇪🇨 Nicolás Lapentti (first round)

• # 🇪🇸 Albert Portas (first round)

• # 🇫🇷 Marc Gicquel (first round)

• # 🇩🇪 Michael Berrer (first round)

• # Melle van Gemerden (qualifying competition)

Qualifiers
• # Novak Djokovic

• # 🇨🇿 Jan Hernych

• # Benjamin Balleret

• # 🇷🇺 Teymuraz Gabashvili

• # 🇷🇺 Evgeny Korolev

• # 🇮🇹 Potito Starace

• # 🇫🇷 Nicolas Mahut

• # 🇮🇹 Alessio di Mauro

Lucky loser

 * 1) 🇮🇹 Daniele Bracciali