2006 NASDAQ-100 Open – Women's singles

Svetlana Kuznetsova defeated Maria Sharapova in the final, 6–4, 6–3 to win the women's singles tennis title at the 2006 Miami Open. It was her first Tier I title and sixth overall, and her first title of any kind since September 2004.

Kim Clijsters was the defending champion, but lost in the second round to Jill Craybas.

Seeds
All seeds received a bye into the second round. • # 🇫🇷 Amélie Mauresmo (semifinals)

• # 🇧🇪 Kim Clijsters (second round)

• # 🇧🇪 Justine Henin-Hardenne (second round)

• # 🇷🇺 Maria Sharapova (final)

• # 🇷🇺 Nadia Petrova (quarterfinals)

• # 🇷🇺 Elena Dementieva (fourth round)

• # Patty Schnyder (fourth round, withdrew)

• # 🇺🇸 Venus Williams (withdrew due to a right elbow ligament strain)

• # 🇮🇹 Francesca Schiavone (second round)

• # 🇷🇺 Anastasia Myskina (quarterfinals)

• # 🇨🇿 Nicole Vaidišová (withdrew due to a right shoulder injury)

• # 🇷🇺 Svetlana Kuznetsova (champion)

• # 🇸🇰 Daniela Hantuchová (third round)

• # Ana Ivanovic (fourth round)

• # 🇷🇺 Elena Likhovtseva (third round)

• # 🇩🇪 Anna-Lena Grönefeld (third round)

• # 🇮🇹 Flavia Pennetta (withdrew due to a right ankle sprain)

• # 🇷🇺 Dinara Safina (second round)

• # 🇫🇷 Nathalie Dechy (second round)

• # 🇷🇺 Maria Kirilenko (fourth round)

• # 🇯🇵 Ai Sugiyama (quarterfinals)

• # 🇫🇷 Tatiana Golovin (semifinals, retired)

• # 🇪🇸 Anabel Medina Garrigues (second round)

• # Martina Hingis (third round)

• # Jelena Janković (second round)

• # 🇦🇷 Gisela Dulko (second round)

• # 🇨🇿 Klára Koukalová (third round)

• # Katarina Srebotnik (third round)

• # 🇨🇿 Lucie Šafářová (second round)

• # 🇫🇷 Marion Bartoli (third round)

• # 🇮🇱 Shahar Pe'er (second round)

• # 🇸🇪 Sofia Arvidsson (fourth round)

• # 🇨🇿 Květa Peschke (second round)