2006 Open de Moselle – Singles

Ivan Ljubičić was the defending champion, but did not participate.

Novak Djokovic won the title, defeating Jürgen Melzer 4–6, 6–3, 6–2 in the final.

By winning this tournament, Djokovic became ATP nr. 16, entering the Top 20 for the first time in his career.

Seeds
• # 🇪🇸 David Ferrer (first round)

• # 🇪🇸 Juan Carlos Ferrero (first round)

• # 🇷🇸 Novak Djokovic (champion)

• # 🇷🇺 Mikhail Youzhny (first round)

• # 🇫🇷 Richard Gasquet (second round)

• # 🇸🇰 Dominik Hrbatý (first round)

• # 🇪🇸 Fernando Verdasco (first round)

• # 🇸🇪 Robin Söderling (first round)