2006 Pilot Pen Tennis – Men's singles

James Blake was the defending champion, but lost to Rubén Ramírez Hidalgo in the second round.

Nikolay Davydenko won the title, defeating Agustín Calleri 6–4, 6–3 in the final.

Seeds
All seeds receive a bye into the second round. • # 🇺🇸 James Blake (second round)

• # 🇷🇺 Nikolay Davydenko (champion)

• # 🇨🇾 Marcos Baghdatis (third round)

• # 🇫🇮 Jarkko Nieminen (third round)

• # 🇪🇸 David Ferrer (third round)

• # 🇦🇷 José Acasuso (third round)

• # 🇪🇸 Fernando Verdasco (third round, retired due to an ankle injury)

• # 🇧🇪 Olivier Rochus (quarterfinals)

• # 🇫🇷 Gaël Monfils (third round)

• # 🇦🇷 Agustín Calleri (final)

• # 🇸🇪 Jonas Björkman (withdrew due to a back injury)

• # 🇦🇷 Juan Ignacio Chela (quarterfinals)

• # 🇧🇪 Xavier Malisse (semifinals, retired due to an elbow injury)

• # Nicolás Massú (quarterfinals)

• # 🇸🇪 Robin Söderling (semifinals)

• # 🇹🇭 Paradorn Srichaphan (third round)